Leptin and insulin suppress appetite in rats

While leptin and insulin signaling in rodents appear to be much simpler than in humans, it appears that their signaling is improved when the rodents are fed a lower fat diet.

Obviosly the type of fat used is critical. I know omega-3 fatty acids and monounsaturated fats improve insulin signaling and probably leptin signaling as well. Saturated fats, trans fats and excess omega-6 polyunsaturated fats most likely are the real culprits here.


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