Leptin decreases fat pad deposits independent of norepinephrine

Norepinephrine stimulates a fat cell to mobilize its fatty acids into the blood stream (lipolysis) to be utilized by the muscles as fuel.

Rats were injected with leptin, which induced a reduction in fat pad size without an increase in norepinephrine, perhaps through a different mechanism.

Leptin is a central part of the pathway that signals the brain on the status of body fat levels. Leptin injected into rodents induces fat loss, but does not work the same way in humans due to a more complex signalling pathway.


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