Obese women have impaired leptin signaling which lowers insulin sensitivity

Compared to lean women, obese women have impaired leptin signaling leading to reduced insulin sensitivity. The defective signaling appears to be related to leptin receptors in subcutaneous fat but not visceral fat.

Leptin signals body fat levels to the brain, affecting appetite. High leptin levels are usually found in obese people (due to high body fat levels) but the message may not get through to the brain (because of impaired leptin signaling).


One Response

  1. Rho October 31, 2007

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