Obesity results in loss of bone mineral density in both postmenopausal women and female mice. Younger females are protect by their higher levels of circulating estrogen. This places obese women at greater risk of osteopenia and osteoporosis.

The relationship between obesity and bone mineral loss suggests causes that are most likely multifaceted and may included Vitamin D deficiency and low grade acidosis where calcium is leached out of bone tissue to buffer acidified body fluids.

PMID: 17712115